This sample shows how to embed wxPython into a wxWidgets application. There are a few little tricks needed to make it work, but once over the hurdle it should work just fine for you. I'll try to describe the build issues here, see the code and comments in embedded.cpp for examples of how to use it. 1. The most important thing is that your wx application and wxPython must use the same version and the same instance of wxWidgets. That means that you can not statically link your app with wxWidgets, but must use a dynamic library for wxWidgets. 2. You must ensure that your app and wxPython are using the same wxWidgets DLL. By default on MSW wxPython installs the wxWidgets DLL to a directory not on the PATH, so you may have to do something creative to make that happen. But because of #3 this may not be that big of a problem. 3. wxPython, your app and wxWidgets must be built with the same flags and settings. This probably means that you will need to rebuild wxPython yourself. I do distribute the setup.h, other headers, import libs and etc. that I use, but you'll need to rebuild everything yourself anyway to get debugger versions so I'm not too worried about it just yet. BTW, on MSW if you do debug builds of your app and wxPython then you will need to have a debug version of Python built too since it expects to have extension modules in files with a _d in the name. If you do a hybrid build then you will be able to use the stock version of Python, but you won't be able to trace through the PYTHON API functions. 4. I expect that most of these issues will be much more minor on Unix. ;-)